Primary spinal epidural rhabdomyosarcoma: a case report and review of the literature

Childs Nerv Syst. 2012 Nov;28(11):1977-80. doi: 10.1007/s00381-012-1822-9. Epub 2012 Jun 6.

Abstract

Background: Primary intraspinal sarcomas are very rare in children. Rhabdomyosarcoma (RMS) is a highly aggressive and rapidly growing sarcoma with skeletal origin that occasionally appears in the spinal epidural space.

Method: We report a 13-year-old girl who presented with back pain, progressive paraparesis, and urinary retention. She had muscular weakness in her lower extremities and absent deep tendon reflex. An epidural dumbbell-shape mass at T11-T12 level was observed on MRI. The patient underwent T12 hemilaminectomy, partial T11 hemilaminectomy, and right facetectomy. A large, firm, dark-red vascular epidural tumor was found compressing the cord. The tumor which extended to intracanal and foraminal parts was removed completely.

Discussion: Histopathological examination revealed undifferentiated small round and oval tumoral cells. Immunohistochemical staining was positive for vimentin, desmin, and myogenin. The final diagnosis was alveolar RMS. She received radiotherapy and chemotherapy by vincristine, actinomycin-D, doxorubicin, and ifosfamide. The patient was in good condition with no tumor recurrence or metastasis at the 1-year follow-up.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Epidural Neoplasms / diagnosis*
  • Epidural Neoplasms / surgery*
  • Epidural Space / pathology*
  • Facial Bones / surgery
  • Female
  • Humans
  • Laminectomy / methods*
  • Magnetic Resonance Imaging
  • Myogenin / metabolism
  • Rhabdomyosarcoma / diagnosis*
  • Rhabdomyosarcoma / surgery*
  • Tomography, X-Ray Computed

Substances

  • Myogenin