Life-threatening ANCA-positive vasculitis associated with rickettsial infection

BMJ Case Rep. 2012 May 30;2012:bcr0320125993. doi: 10.1136/bcr.03.2012.5993.

Abstract

We present a 47-year-old Caucasian fire fighter who developed multisystem organ failure in the setting of a positive antineutrophil cytoplasmic autoantibody (myeloperoxidase) as well as confirmed Rocky Mountain spotted fever by skin biopsy PCR. This case provided a diagnostic challenge, a rare association of a Rickettsia infection and autoimmune vasculitis as well as a unique management approach.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Antineutrophil Cytoplasmic / immunology*
  • Biopsy
  • DNA, Bacterial / analysis
  • Humans
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Rickettsia rickettsii / genetics
  • Rickettsia rickettsii / immunology
  • Rickettsia rickettsii / isolation & purification*
  • Rocky Mountain Spotted Fever / complications*
  • Rocky Mountain Spotted Fever / immunology
  • Rocky Mountain Spotted Fever / parasitology
  • Skin / blood supply
  • Skin / parasitology
  • Skin / pathology*
  • Vasculitis / etiology*
  • Vasculitis / immunology

Substances

  • Antibodies, Antineutrophil Cytoplasmic
  • DNA, Bacterial