Metastases and primary tumors around dental implants: A literature review and case report of peri-implant pulmonary metastasis

Quintessence Int. 2012 Jul-Aug;43(7):563-70.


Objective: To perform a literature review on peri-implant metastases and primary malignoma and report a case of a pulmonary metastasis around dental implants of the anterior mandibular jaw that mimicked peri-implantitis.

Method and materials: A literature search of publications from June 1980 to June 2011 in the PubMed/Medline database was performed to collect information about the type, incidence, and localization of malignant primary tumors and metastases around dental implants and to evaluate potential risk factors. A descriptive statistic was performed based on the collected data with regard to the type and/or origin of tumor, its localization, and the patient's age and sex.

Results: A total of 1,795 articles were considered for evaluation. Peri-implant metastases are described in three articles, and peri-implant primary tumors were found in 14 publications. Of all peri-implant metastases, no associated risk factors are mentioned. Those of the peri-implant tumors are alterations of the peri-implant mucosa (such as oral lichen planus, verrucous leukoplakia, and ulcer). Most of the primary tumors are squamous cell carcinoma. The mean age of the patients with peri-implant metastases was 68 years; for the peri-implant primary tumors, it was 71 years.

Conclusion: Peri-implant metastases and primary tumors are rare. Every untypical or refractory reaction to the treatment of peri-implantitis is suspicious for malignancy as long as the contrary remains unproven.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Carcinoma, Non-Small-Cell Lung / secondary*
  • Carcinoma, Squamous Cell / pathology
  • Dental Implants*
  • Diagnosis, Differential
  • Fatal Outcome
  • Female
  • Gingival Neoplasms / pathology*
  • Gingival Neoplasms / secondary*
  • Humans
  • Leukoplakia, Oral / pathology
  • Lichen Planus, Oral / pathology
  • Lung Neoplasms / pathology*
  • Mandibular Neoplasms / secondary*
  • Middle Aged
  • Oral Ulcer / pathology
  • Peri-Implantitis / pathology
  • Plasmacytoma / pathology
  • Risk Factors


  • Dental Implants