Comparative antiplaque and antigingivitis efficacy of a multipurpose essential oil-containing mouthrinse and a cetylpyridinium chloride-containing mouthrinse: A 6-month randomized clinical trial

Quintessence Int. Jul-Aug 2012;43(7):e82-94.


Objective: This 6-month, examiner-blind, single-center, randomized, parallel group clinical trial compared the antiplaque and antigingivitis effects of an essential oil-containing mouthrinse with zinc chloride and sodium fluoride (EO) to a 0.05% cetylpyridinium chloride-containing mouthrinse (CPC) also with fluoride.

Method and materials: Four hundred and eight gingivitis subjects were monitored for the primary outcomes of modified Gingival Index (MGI) and Plaque Index (PI) at baseline and 3 and 6 months. Subjects were randomly assigned to 6-month twice a day unsupervised use of EO, CPC, or negative control rinse in conjunction with normal brushing and flossing.

Results: EO was always better than CPC at 3 and 6 months considering all parameters. All benefits allowed by EO increased from 3 to 6 months. CPC was better than the negative control at 3 and 6 months with respect to whole mouth plaque, and the proportion of more severe sites (baseline scores ≥ 3) in PI and MGI. At 6 months, CPC did not differ from negative control in relation to whole mouth MGI reduction, proximal MGI reduction, and percentages of sites improved over baseline in PI and MGI.

Conclusion: This new EO mouthrinse provided superior clinical benefits to CPC and demonstrated increasing plaque and gingivitis reductions over 6 months. Our findings support the regular long-term use of the EO mouthrinse and selection over a 0.05% CPC rinse for better efficacy.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Analysis of Variance
  • Anti-Infective Agents, Local / therapeutic use*
  • Cetylpyridinium / therapeutic use*
  • Chlorides / therapeutic use
  • Dental Plaque / prevention & control*
  • Dental Plaque Index
  • Female
  • Gingivitis / prevention & control*
  • Humans
  • Longitudinal Studies
  • Male
  • Mouthwashes / chemistry
  • Mouthwashes / therapeutic use*
  • Oils, Volatile / therapeutic use*
  • Periodontal Index
  • Single-Blind Method
  • Sodium Fluoride / therapeutic use
  • Zinc Compounds / therapeutic use


  • Anti-Infective Agents, Local
  • Chlorides
  • Mouthwashes
  • Oils, Volatile
  • Zinc Compounds
  • zinc chloride
  • Sodium Fluoride
  • Cetylpyridinium