Antioxidant, Antihyperglycemic, and Antihyperlipidemic Effects of Coriandrum Sativum Leaf and Stem in Alloxan-Induced Diabetic Rats

J Food Sci. 2012 Jul;77(7):T119-23. doi: 10.1111/j.1750-3841.2012.02755.x. Epub 2012 Jun 1.

Abstract

In India's indigenous system of medicine, Coriandrum sativum (CS), commonly used as a food ingredient, is claimed to be useful for various ailments. To establish its utility in diabetes mellitus, the present study evaluated the antidiabetic and antioxidant effects of CS in alloxan-induced diabetic rats. The extracts were shown to contain bioactive compounds including phenolics, flavonoids, steroids, and tannins. The extracts of CS in alloxan-induced diabetic rats were found to significantly lower blood glucose levels. Antidiabetic activity of the CS extracts was compared with the clinically available drug glibenclamide. The levels of serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol were lower in the extract-treated group and high-density lipoprotein cholesterol was higher than the diabetic control rats. The extracts of CS exhibited strong scavenging effect on 2, 2-diphenyl-2-picrylhydrazyl free radical and inhibition of lipid peroxidation. The free radical scavenging effect of the extracts was comparable with that of the reference antioxidants. Furthermore, it also showed an improved antioxidant potential as evidenced by decreased lipid peroxidation and a significant increase in the activity of various antioxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase in the liver of diabetic rats. These results indicate that the extracts could protect liver function and exhibited hypoglycemic, hypolipidemic, and antioxidant efficacies in the diabetic rats. These results support the use of this plant extract to manage diabetes mellitus.

Practical applications: The leaves and stem of this plant Coriandrum sativum if used in cuisine would be a remedy for diabetes.

MeSH terms

  • Alloxan / toxicity
  • Animals
  • Antioxidants / pharmacology*
  • Blood Glucose / drug effects
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Coriandrum / chemistry*
  • Diabetes Mellitus, Experimental / chemically induced
  • Diabetes Mellitus, Experimental / drug therapy*
  • Diabetes Mellitus, Experimental / pathology
  • Glyburide / pharmacology
  • Hypoglycemic Agents / pharmacology*
  • Hypolipidemic Agents / pharmacology*
  • India
  • Lipid Peroxidation / drug effects
  • Liver / drug effects
  • Liver / metabolism
  • Liver / pathology
  • Plant Extracts / pharmacology*
  • Plant Leaves / chemistry
  • Plant Stems / chemistry
  • Rats
  • Rats, Wistar
  • Triglycerides / blood

Substances

  • Antioxidants
  • Blood Glucose
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Hypoglycemic Agents
  • Hypolipidemic Agents
  • Plant Extracts
  • Triglycerides
  • Alloxan
  • Glyburide