Biomarkers intersect with the exposome

Biomarkers. 2012 Sep;17(6):483-9. doi: 10.3109/1354750X.2012.691553. Epub 2012 Jun 7.


The exposome concept promotes use of omic tools for discovering biomarkers of exposure and biomarkers of disease in studies of diseased and healthy populations. A two-stage scheme is presented for profiling omic features in serum to discover molecular biomarkers and then for applying these biomarkers in follow-up studies. The initial component, referred to as an exposome-wide-association study (EWAS), employs metabolomics and proteomics to interrogate the serum exposome and, ultimately, to identify, validate and differentiate biomarkers of exposure and biomarkers of disease. Follow-up studies employ knowledge-driven designs to explore disease causality, prevention, diagnosis, prognosis and treatment.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Biomarkers / blood
  • Blood Proteins / metabolism*
  • Cardiovascular Diseases / blood
  • Environmental Exposure
  • Humans
  • Metabolome*
  • Metabolomics
  • Neoplasms / blood
  • Neurodegenerative Diseases / blood
  • Proteome / metabolism*
  • Proteomics


  • Biomarkers
  • Blood Proteins
  • Proteome