Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation

FEBS Lett. 2012 May 21;586(10):1547-54. doi: 10.1016/j.febslet.2012.04.021. Epub 2012 Apr 21.


Synapsins are neuronal phosphoproteins that coat synaptic vesicles and are believed to function in the regulation of neurotransmitter release. The signaling mechanism for short-chain free fatty acid (SCFA)-stimulated NE release was examined using primary-cultured mouse sympathetic cervical ganglion neurons. Pharmacological and knockdown experiments showed that activation of sympathetic neurons by SCFA propionate involves SCFA receptor GPR41 linking to G??-PLC?3-ERK1/2-synapsin 2 signaling. Further, synapsin 2b directly interacts with activated ERK1/2 and can be phosphorylated on serine when SCFA activates sympathetic neurons.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Cells, Cultured
  • DNA Primers
  • Extracellular Signal-Regulated MAP Kinases / metabolism
  • Mice
  • Neurons / physiology*
  • Phosphorylation
  • Polymerase Chain Reaction
  • RNA, Small Interfering / genetics
  • Receptors, G-Protein-Coupled / physiology*
  • Sympathetic Nervous System / cytology
  • Synapsins / metabolism*


  • DNA Primers
  • Gpcr41 protein, mouse
  • RNA, Small Interfering
  • Receptors, G-Protein-Coupled
  • Synapsins
  • Extracellular Signal-Regulated MAP Kinases