[Community-acquired Staphylococcus aureus necrotizing pneumonia secreting Panton-Valentine leukocidin in an infant]

Arch Pediatr. 2012 Jul;19(7):718-21. doi: 10.1016/j.arcped.2012.04.027. Epub 2012 Jun 4.
[Article in French]

Abstract

Staphylococcus aureus (SA) necrotizing pneumonia secreting Panton-Valentine leukocidin (PVL) has a high mortality rate, approximately 50% according to recent data, mainly in children and young adults. Recently, 2 cases of the disease have been reported in newborn twins with a good outcome. We report a third case of community-acquired necrotizing pneumonia due to SA sensitive to methicillin (SASM) secreting Panton-Valentine leukocidin (PVL) in an infant, initially paucisymptomatic, in the context of familial furunculosis, with a fatal outcome. Cases of necrotizing pneumonia in this age group are emerging, and extensive information for clinicians is needed due to the high mortality rate of the disease.

Publication types

  • Case Reports

MeSH terms

  • Bacterial Toxins
  • Community-Acquired Infections / metabolism
  • Community-Acquired Infections / pathology
  • Exotoxins / metabolism*
  • Humans
  • Infant
  • Leukocidins / metabolism*
  • Male
  • Necrosis
  • Pneumonia, Staphylococcal / metabolism*
  • Pneumonia, Staphylococcal / pathology
  • Staphylococcus aureus*

Substances

  • Bacterial Toxins
  • Exotoxins
  • Leukocidins
  • Panton-Valentine leukocidin