Subclinical zinc deficiency impairs human brain function

J Trace Elem Med Biol. 2012 Jun;26(2-3):70-3. doi: 10.1016/j.jtemb.2012.04.018. Epub 2012 Jun 4.


Experiments in other species showed zinc essential for brain growth and function. Six randomized controlled comparative treatment experiments in Chinese and Mexican-American low-income children, aged 6-9 years, middle-income US adolescents, middle-income US premenopausal women and middle income US men, found that subclinical zinc deficiency changes brain function. Simultaneous treatment with a broad mixture of other micronutrients and/or an adequate omnivorous diet appeared to enhance the efficacy of zinc.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Brain / metabolism*
  • Brain / physiology*
  • Cognition / physiology
  • Humans
  • Memory / physiology
  • Psychomotor Performance / physiology
  • Zinc / deficiency*
  • Zinc / metabolism


  • Zinc