Antioxidant vitamins prevent oxidative and carbonyl stress in an animal model of obstructive sleep apnea

Sleep Breath. 2013 May;17(2):867-71. doi: 10.1007/s11325-012-0728-9. Epub 2012 Jun 7.


Purpose: The aim of our study was to analyze the effects of an antioxidant treatment on markers of oxidative and carbonyl stress in a rat model of obstructive sleep apnea.

Methods: Wistar rats were randomized into six groups-according to gender and intervention-sham, intermittent hypoxia, and intermittent hypoxia with treatment by vitamins C and E. Rats underwent tracheostomy. The tracheal cannula was closed for 12 s every minute for 1 h to simulate obstructive sleep apnea-related intermittent hypoxia. In the treatment group, rats received vitamin C and E 24 h prior to surgery.

Results: The intervention had a significant effect on advanced oxidation protein products (p = 0.008) and advanced glycation end products-specific fluorescence (p = 0.006) but no effect on malondialdehyde. Oxidation and glycation protein products were higher in intermittent hypoxia groups than in sham and in treated groups.

Conclusions: Antioxidants alleviate oxidative and carbonyl stress in an experimental model of obstructive sleep apnea. Future studies will show whether such treatment has any clinical value regarding cardiovascular complications of sleep apnea syndrome, preferably in patients with low compliance to continuous positive airway pressure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Advanced Oxidation Protein Products / drug effects
  • Advanced Oxidation Protein Products / physiology
  • Animals
  • Ascorbic Acid / pharmacology*
  • Disease Models, Animal*
  • Female
  • Male
  • Malondialdehyde / blood
  • Oxidative Stress / drug effects*
  • Oxidative Stress / physiology*
  • Protein Carbonylation / drug effects*
  • Protein Carbonylation / physiology*
  • Rats
  • Rats, Wistar
  • Sleep Apnea, Obstructive / physiopathology*
  • Thiobarbituric Acid Reactive Substances / metabolism
  • Vitamin E / pharmacology*


  • Advanced Oxidation Protein Products
  • Thiobarbituric Acid Reactive Substances
  • Vitamin E
  • Malondialdehyde
  • Ascorbic Acid