Microbiota, disease, and back to health: a metastable journey

Sci Transl Med. 2012 Jun 6;4(137):137rv7. doi: 10.1126/scitranslmed.3004184.


Alterations in the composition of the commensal microbiota have been observed in many complex diseases. Understanding the basis for these changes, how they relate to disease risk or activity, and the mechanisms by which the symbiotic state of colonization resistance and host homeostasis is restored is critical for future therapies aimed at manipulating the microbiota.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Gastrointestinal Tract / microbiology
  • Health*
  • Humans
  • Inflammatory Bowel Diseases / microbiology
  • Metagenome / physiology*