Clinical approach to Parkinson's disease: features, diagnosis, and principles of management

Cold Spring Harb Perspect Med. 2012 Jun;2(6):a008870. doi: 10.1101/cshperspect.a008870.


Parkinson's disease (PD) is one of the most common neurodegenerative disorders. The condition causes a heavy burden both on those affected, as well as their families. Accurate diagnosis is critical and remains founded on clinical grounds as no specific diagnostic test is available so far. The clinical picture of PD is typical in many instances; however, features distinguishing it from other disorders should be thoroughly sought. Monogenic forms of PD also have some distinctive characteristics in many cases. This text is a roadmap to accurate diagnosis in PD, as it approaches clinical features, diagnostic methodology, and leading differential diagnoses. Therapeutic issues are also briefly discussed.

Publication types

  • Video-Audio Media

MeSH terms

  • Antiparkinson Agents / therapeutic use
  • Deep Brain Stimulation
  • Humans
  • Parkinson Disease / diagnosis*
  • Parkinson Disease / genetics
  • Parkinson Disease / therapy


  • Antiparkinson Agents