"Embryo glue" does not seem to improve chances of subsequent pregnancy in refractory in vitro fertilization cases

Clin Exp Obstet Gynecol. 2012;39(1):11-2.


Purpose: To determine if the use of Embryo glue improves implantation and pregnancy rates following embryo transfer (ET) in women who failed to conceive in three previous attempts.

Methods: A matched controlled study was performed in women undergoing IVF-ET, donor oocyte recipients and women using their own oocytes having fresh or frozen ETs. A woman having Embryo glue was matched with the very next woman not using glue within six months of age and having the same number of previous failed ETs.

Results: Embryo glue did not seem to improve pregnancy or implantation rates. In fact, in evaluating fresh embryo transfers there was a significantly higher live delivered pregnancy rate in the women not using Embryo glue (39.3%) vs those using the glue (14.3%).

Conclusions: Embryo glue does not improve pregnancy outcome in women failing in previous IVF cycles.

Publication types

  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Embryo Implantation / drug effects*
  • Embryo Transfer*
  • Female
  • Humans
  • Hyaluronic Acid*
  • Pregnancy
  • Pregnancy Rate*


  • Embryo glue
  • Hyaluronic Acid