Circumcision and penile human papillomavirus prevalence in human immunodeficiency virus-infected men: heterosexual and men who have sex with men

Clin Microbiol Infect. 2013 Jul;19(7):611-6. doi: 10.1111/j.1469-0691.2012.03911.x. Epub 2012 Jun 8.

Abstract

Male circumcision is associated with a lower risk of penile human papillomavirus (HPV) infection in human immunodeficiency virus (HIV) uninfected men. Few studies have evaluated the role of male circumcision in penile HPV infection in HIV-infected men. The aim of this cross-sectional study was to examine the association between male circumcision and the prevalence of penile HPV infection among HIV-infected men-both men who have sex with men (MSM) and heterosexual men. Samples from 706 consecutive men included in the CARH-MEN cohort (overall 24% circumcised: 26% of MSM, 18% of heterosexual men) were examined by Multiplex-PCR. In the overall group (all HIV-infected men included), the prevalence of any penile HPV infection was 22% in circumcised men and 27% in uncircumcised men (OR = 1.0, 95% CI 0.6-1.6, adjusted analysis). In the circumcised group the overall prevalence of HPV infection was 22% in MSM and 24% in the heterosexual men, whereas in the uncircumcised group the prevalence was 26% and 28%, respectively. The prevalence of high-risk HPV types tended to be lower in the circumcised MSM (14% vs 21%, OR = 0.6, 95% CI 0.3-1.1, p 0.088), but it was similar in the heterosexual men (18% in circumcised vs 20% in uncircumcised). These results suggest that male circumcision may be associated with a lower prevalence of oncogenic high-risk penile HPV infection in HIV-infected MSM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Circumcision, Male*
  • Cross-Sectional Studies
  • DNA, Viral / genetics
  • DNA, Viral / isolation & purification
  • HIV Infections / complications*
  • Heterosexuality
  • Homosexuality, Male
  • Humans
  • Male
  • Middle Aged
  • Multiplex Polymerase Chain Reaction
  • Papillomaviridae / classification
  • Papillomaviridae / isolation & purification
  • Papillomavirus Infections / epidemiology*
  • Penile Diseases / epidemiology*
  • Prevalence
  • Young Adult

Substances

  • DNA, Viral