CD22 and Siglec-G in B cell function and tolerance

Trends Immunol. 2012 Aug;33(8):413-20. doi: 10.1016/ Epub 2012 Jun 5.


The immune system has evolved into two main arms: the primitive innate arm that is the first line of defense but relatively short-lived and broad acting; and the advanced adaptive arm that generates immunological memory, allowing rapid, specific recall responses. T cell-independent type-2 (TI-2) antigens (Ags) invoke innate immune responses. However, due to its 'at the ready' nature, how the innate arm of the immune system maintains tolerance to potentially abundant host TI-2 Ags remains elusive. Therefore, it is important to define the mechanisms that establish innate immune tolerance. This review highlights recent insights into B cell tolerance to theoretical self TI-2 Ags, and examines how the B cell-restricted sialic acid binding Ig-like lectins (Siglecs), CD22 and Siglec-G, might contribute to this process.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology
  • B-Lymphocytes / immunology*
  • Humans
  • Immune Tolerance*
  • Lectins / immunology*
  • Receptors, Antigen, B-Cell / immunology*
  • Sialic Acid Binding Ig-like Lectin 2 / immunology*


  • Lectins
  • Receptors, Antigen, B-Cell
  • Sialic Acid Binding Ig-like Lectin 2