Corpus callosum atrophy--a simple predictor of multiple sclerosis progression: a longitudinal 9-year study

Eur Neurol. 2012;68(1):23-7. doi: 10.1159/000337683. Epub 2012 Jun 6.


Aim: To determine whether corpus callosum atrophy predicts future clinical deterioration in multiple sclerosis.

Methods: In 39 multiple sclerosis patients the area of corpus callosum in the sagittal plane, T2 and T1 lesion volumes, brain parenchymal fraction and brain atrophy were determined at baseline and 1 year after treatment initiation. Non-parametric and multiple regression models were built to identify the most reliable predictors of disability and of its changes over 9 years.

Results: Corpus callosum atrophy during the first year of treatment was the best predictor of disability (r = -0.56) and of its increase at 9 years (r = 0.65). Corpus callosum atrophy of at least 2% predicted increase in disability with 93% sensitivity and 73% specificity (odds ratio = 35).

Conclusion: Corpus callosum atrophy is a simple and accurate predictor of future disability accumulation and is feasible for routine clinical practice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Atrophy / pathology
  • Corpus Callosum / pathology*
  • Disease Progression
  • Female
  • Humans
  • Longitudinal Studies
  • Magnetic Resonance Imaging
  • Male
  • Multiple Sclerosis, Relapsing-Remitting / pathology*
  • Retrospective Studies
  • Sensitivity and Specificity