An approach to the management of hyperbilirubinemia in the preterm infant less than 35 weeks of gestation

J Perinatol. 2012 Sep;32(9):660-4. doi: 10.1038/jp.2012.71. Epub 2012 Jun 7.


We provide an approach to the use of phototherapy and exchange transfusion in the management of hyperbilirubinemia in preterm infants of <35 weeks of gestation. Because there are limited data for evidence-based recommendations, these recommendations are, of necessity, consensus-based. The recommended treatment levels are based on operational thresholds for bilirubin levels and represent those levels beyond which it is assumed that treatment will likely do more good than harm. Long-term follow-up of a large population will be needed to evaluate whether or not these recommendations should be modified.

Publication types

  • Review

MeSH terms

  • Bilirubin / physiology
  • Exchange Transfusion, Whole Blood*
  • Humans
  • Hyperbilirubinemia, Neonatal / physiopathology
  • Hyperbilirubinemia, Neonatal / therapy*
  • Infant, Extremely Low Birth Weight
  • Infant, Newborn
  • Infant, Premature
  • Infant, Premature, Diseases / therapy*
  • Phototherapy*


  • Bilirubin