Post-translational modulation of pluripotency

J Mol Cell Biol. 2012 Aug;4(4):262-5. doi: 10.1093/jmcb/mjs031. Epub 2012 Jun 7.


The maintenance of pluripotency relies on an intricate transcriptional network hinged on a key set of transcription factors. Pluripotent stem cells have been shown to be sensitive to modulations of the cellular abundance and transcriptional activity of these key pluripotency factors. Recent evidence highlights the important role of post-translational modifications, including ubiquitination, sumoylation, phosphorylation, methylation, and acetylation, in regulating the levels and activity of pluripotency factors to achieve a balance between pluripotency and differentiation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Models, Biological
  • Pluripotent Stem Cells / metabolism*
  • Protein Processing, Post-Translational*
  • Small Ubiquitin-Related Modifier Proteins / metabolism
  • Transcription Factors / metabolism


  • Small Ubiquitin-Related Modifier Proteins
  • Transcription Factors