An unusual case of DRESS syndrome due to leflunomide

BMJ Case Rep. 2011 Sep 4:2011:bcr0620114330. doi: 10.1136/bcr.06.2011.4330.


The DRESS (drug rash, eosinophilia and systemic symptoms) syndrome, is a type of drug hypersensitivity syndrome, is a severe idiosyncratic reaction to several drugs, mainly antiepileptics and antibiotics, which can occasionally produce acute hepatic failure. In this article, the authors report a case of DRESS syndrome with severe exfoliative dermatitis with acute hepatitis associated with intake of leflunomide. Rapid diagnosis with withdrawal of offending agent is crucial for survival of these cases.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Candidiasis, Oral / chemically induced
  • Diagnosis, Differential
  • Drug Eruptions / diagnosis*
  • Eosinophilia / chemically induced*
  • Humans
  • Isoxazoles / adverse effects*
  • Leflunomide
  • Male
  • Syndrome


  • Anti-Inflammatory Agents, Non-Steroidal
  • Isoxazoles
  • Leflunomide