Abstract
Calophyline A (1), a novel unprecedented rearranged monoterpenoid indole alkaloid, along with a new natural product N-methyl aspidodasycarpine (2) and six known analogues, was isolated from the trunk barks of Winchia calophylla. The structure of compound 1 was elucidated on the basis of spectroscopic data and then confirmed by a single-crystal X-ray crystallographic analysis. A hypothetical biogenetic pathway for compound 1 was proposed. All isolated compounds were evaluated for their in vitro cytotoxicity against a small panel of human cancer cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Apocynaceae / chemistry*
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Cell Line, Tumor
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Crystallography, X-Ray
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Humans
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Models, Molecular
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Molecular Conformation
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Plant Bark / chemistry
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Plant Extracts / chemistry
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Secologanin Tryptamine Alkaloids / chemistry
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Secologanin Tryptamine Alkaloids / isolation & purification
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Secologanin Tryptamine Alkaloids / pharmacology*
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Antineoplastic Agents, Phytogenic
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Plant Extracts
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Secologanin Tryptamine Alkaloids
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calophyline A