Obstructed diffusion propagator analysis for single-particle tracking

Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Apr;85(4 Pt 1):041924. doi: 10.1103/PhysRevE.85.041924. Epub 2012 Apr 30.


We describe a method for the analysis of the distribution of displacements, i.e., the propagators, of single-particle tracking measurements for the case of obstructed subdiffusion in two-dimensional membranes. The propagator for the percolation cluster is compared with a two-component mobility model against Monte Carlo simulations. To account for diffusion in the presence of obstacle concentrations below the percolation threshold, a propagator that includes the transient motion in finite percolation clusters and hopping between obstacle-induced compartments is derived. Finally, these models are shown to be effective in the analysis of Kv2.1 channel diffusive measurements in the membrane of living mammalian cells.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Equipment Design
  • Equipment Failure Analysis
  • Molecular Imaging / instrumentation*
  • Motion
  • Nanoparticles / ultrastructure*
  • Refractometry / instrumentation*