When death was young: an ancestral apoptotic network in bacteria

Mol Cell. 2012 Jun 8;46(5):552-4. doi: 10.1016/j.molcel.2012.05.032.


In this issue of Molecular Cell, Dwyer et al. (2012) characterize a RecA-dependent and ClpXP-regulated pathway that controls the acquisition of several apoptotic markers upon bactericidal treatment of prokaryotes, placing the hypothetical origin of apoptosis further downstream in evolution.

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