Structure and pharmacology of pentameric receptor channels: from bacteria to brain

Structure. 2012 Jun 6;20(6):941-56. doi: 10.1016/j.str.2012.05.003.


Orthologs of the pentameric receptor channels that mediate fast synaptic transmission in the central and peripheral nervous systems have been found in several bacterial species and in a single archaea genus. Recent X-ray structures of bacterial and invertebrate pentameric receptors point to a striking conservation of the structural features within the whole family, even between distant prokaryotic and eukaryotic members. These structural data reveal general principles of molecular organization that allow allosteric membrane proteins to mediate chemoelectric transduction. Notably, several conformations have been solved, including open and closed channels with distinct global tertiary and quaternary structure. The data reveal features of the ion channel architecture and of diverse categories of binding sites, such as those that bind orthosteric ligands, including neurotransmitters, and those that bind allosteric modulators, such as general anesthetics, ivermectin, or lipids. In this review, we summarize the most recent data, discuss insights into the mechanism of action in these systems, and elaborate on newly opened avenues for drug design.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Allosteric Site
  • Amino Acid Sequence
  • Animals
  • Bacteria*
  • Bacterial Proteins / antagonists & inhibitors
  • Bacterial Proteins / chemistry*
  • Bacterial Proteins / metabolism
  • Brain / metabolism*
  • Conserved Sequence
  • Drug Design
  • Humans
  • Ion Channels / antagonists & inhibitors
  • Ion Channels / chemistry*
  • Ion Channels / metabolism
  • Membrane Transport Modulators / pharmacology
  • Models, Molecular
  • Protein Binding
  • Protein Interaction Domains and Motifs
  • Protein Structure, Quaternary
  • Receptors, Cell Surface / antagonists & inhibitors
  • Receptors, Cell Surface / chemistry*
  • Receptors, Cell Surface / metabolism
  • Signal Transduction
  • Structural Homology, Protein


  • Bacterial Proteins
  • Ion Channels
  • Membrane Transport Modulators
  • Receptors, Cell Surface