Lipid metabolism and toxicity in the heart

Cell Metab. 2012 Jun 6;15(6):805-12. doi: 10.1016/j.cmet.2012.04.006.


The heart has both the greatest caloric needs and the most robust oxidation of fatty acids (FAs). Under pathological conditions such as obesity and type 2 diabetes, cardiac uptake and oxidation are not balanced and hearts accumulate lipid potentially leading to cardiac lipotoxicity. We will first review the pathways utilized by the heart to acquire FAs from the circulation and to store triglyceride intracellularly. Then we will describe mouse models in which excess lipid accumulation causes heart dysfunction and experiments performed to alleviate this toxicity. Finally, the known relationships between heart lipid metabolism and dysfunction in humans will be summarized.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Cardiomyopathies / etiology
  • Cardiomyopathies / metabolism
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / metabolism
  • Energy Metabolism
  • Fatty Acids / blood
  • Fatty Acids / metabolism
  • Humans
  • Lipid Metabolism*
  • Myocardium / metabolism*
  • Myocardium / pathology
  • Obesity / complications
  • Obesity / metabolism


  • Fatty Acids