Field cancerization: something new under the sun

Sakari Vanharanta; Joan Massagué

doi:10.1016/j.cell.2012.05.013

Field cancerization: something new under the sun

Cell. 2012 Jun 8;149(6):1179-81. doi: 10.1016/j.cell.2012.05.013.

Authors

Sakari Vanharanta¹, Joan Massagué

Affiliation

¹ Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

PMID: 22682238
DOI: 10.1016/j.cell.2012.05.013

Abstract

Mutations in keratinocyte and melanocyte precursors that are caused by extensive sun exposure are well-established contributors to skin cancer. Now Hu et al. provide evidence that the sun's harmful rays may also cause tumor-promoting epigenetic modifications in dermal fibroblasts, highlighting further the importance of tumor-stroma interactions in cancer.

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