Field cancerization: something new under the sun

Cell. 2012 Jun 8;149(6):1179-81. doi: 10.1016/j.cell.2012.05.013.


Mutations in keratinocyte and melanocyte precursors that are caused by extensive sun exposure are well-established contributors to skin cancer. Now Hu et al. provide evidence that the sun's harmful rays may also cause tumor-promoting epigenetic modifications in dermal fibroblasts, highlighting further the importance of tumor-stroma interactions in cancer.

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