Tumor suppression by p53: fall of the triumvirate?

Cell. 2012 Jun 8;149(6):1183-5. doi: 10.1016/j.cell.2012.05.024.


p53 is a key tumor suppressor protein that has numerous functions. Its primary mode of action has generally been ascribed to the induction of cell-cycle arrest, apoptosis, or senescence upon stress. Li et al. challenge this dogma with evidence that all three of these programs are dispensable for p53's tumor suppressive role.

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