Target practice: modeling tumors with stem cells

Cell. 2012 Jun 8;149(6):1185-7. doi: 10.1016/j.cell.2012.05.019.


A variant neoplastic line of human pluripotent stem cell (hPSC) displays unique tumorigenic properties, including enhanced self-renewal and survival, and aberrant blockade in differentiation. Sachlos et al. adopted a neoplastic hPSC differentiation platform to screen small molecules that selectively induce differentiation of cancer stem cells.

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