Wnt/β-catenin Signaling and Disease

Cell. 2012 Jun 8;149(6):1192-205. doi: 10.1016/j.cell.2012.05.012.

Abstract

The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease / genetics
  • Humans
  • Wnt Proteins / metabolism*
  • Wnt Signaling Pathway*
  • beta Catenin / metabolism*

Substances

  • Wnt Proteins
  • beta Catenin