Insulin-like growth factor 1 physiology: lessons from mouse models

Endocrinol Metab Clin North Am. 2012 Jun;41(2):231-47, v. doi: 10.1016/j.ecl.2012.04.008. Epub 2012 May 15.

Abstract

Insulin-like growth factor 1 (IGF-1) is a pleiotropic polypeptide. Its expression is tightly regulated and it plays significant roles during early development, maturation, and adulthood. This article discusses the roles of IGF-1 in determination of body size, skeletal acquisition, muscle growth, carbohydrate metabolism, and longevity, as learned from mouse models.

Publication types

  • Review

MeSH terms

  • Animals
  • Body Size / physiology
  • Female
  • Humans
  • Insulin-Like Growth Factor I / physiology*
  • Insulin-Like Growth Factor II / physiology
  • Lipid Metabolism
  • Longevity / physiology
  • Male
  • Mice
  • Models, Animal*
  • Muscle, Skeletal / physiology
  • Reproduction / physiology
  • Signal Transduction / physiology

Substances

  • IGF2 protein, mouse
  • insulin-like growth factor-1, mouse
  • Insulin-Like Growth Factor I
  • Insulin-Like Growth Factor II