Cerebral Venous Sinus Thrombosis: Association With Primary Varicella Zoster Virus Infection

J Stroke Cerebrovasc Dis. 2012 Nov;21(8):917.e1-4. doi: 10.1016/j.jstrokecerebrovasdis.2012.04.013. Epub 2012 Jun 8.

Abstract

Varicella zoster virus (VZV) has been known to cause cerebral arterial vasculopathy and an acquired antibody-mediated coagulopathy associated with purpura fulminans and generalized thromboembolism. There are no published reports of cerebral venous sinus thrombosis (CVST) associated with primary VZV infection. We report 2 cases that highlight an unusual presentation of VZV infection: CVST with primary varicella infection. One patient had extensive CVST with coexistent middle cerebral artery involvement. Primary VZV infection can be associated with thrombosis of cerebral arteries and venous sinuses.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anticoagulants / therapeutic use
  • Antiviral Agents / therapeutic use
  • Cerebral Angiography / methods
  • Cerebral Arteries / pathology
  • Cerebral Arteries / virology*
  • Diffusion Magnetic Resonance Imaging
  • Herpes Zoster / complications
  • Herpes Zoster / diagnosis
  • Herpes Zoster / drug therapy
  • Herpes Zoster / virology*
  • Herpesvirus 3, Human / isolation & purification*
  • Humans
  • Infarction, Middle Cerebral Artery / virology
  • Magnetic Resonance Angiography
  • Male
  • Phlebography / methods
  • Sinus Thrombosis, Intracranial / diagnosis
  • Sinus Thrombosis, Intracranial / drug therapy
  • Sinus Thrombosis, Intracranial / virology*
  • Treatment Outcome
  • Young Adult

Substances

  • Anticoagulants
  • Antiviral Agents