Three dyslexia susceptibility genes, DYX1C1, DCDC2, and KIAA0319, affect temporo-parietal white matter structure

Biol Psychiatry. 2012 Oct 15;72(8):671-6. doi: 10.1016/j.biopsych.2012.05.008. Epub 2012 Jun 9.


Background: Volume and integrity of white matter correlate with reading ability, but the underlying factors contributing to this variability are unknown.

Methods: We investigated single nucleotide polymorphisms in three genes previously associated with dyslexia and implicated in neuronal migration (DYX1C1, DCDC2, KIAA0319) and white matter volume in a cohort of 76 children and young adults from the general population.

Results: We found that all three genes contained polymorphisms that were significantly associated with white matter volume in the left temporo-parietal region and that white matter volume influenced reading ability.

Conclusions: The identified region contained white matter pathways connecting the middle temporal gyrus with the inferior parietal lobe. The finding links previous neuroimaging and genetic results and proposes a mechanism underlying variability in reading ability in both normal and impaired readers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Cytoskeletal Proteins
  • Diffusion Tensor Imaging
  • Female
  • Genetic Association Studies
  • Genotype
  • Humans
  • Imaging, Three-Dimensional
  • Linear Models
  • Male
  • Microtubule-Associated Proteins / genetics*
  • Nerve Fibers, Myelinated*
  • Nerve Tissue Proteins / genetics*
  • Nuclear Proteins / genetics*
  • Parietal Lobe / anatomy & histology*
  • Polymorphism, Single Nucleotide / genetics*
  • Reaction Time / genetics
  • Reading
  • Sweden
  • Temporal Lobe / anatomy & histology*
  • Young Adult


  • Cytoskeletal Proteins
  • DCDC2 protein, human
  • DNAAF4 protein, human
  • KIAA0319 protein, human
  • Microtubule-Associated Proteins
  • Nerve Tissue Proteins
  • Nuclear Proteins