The recreational tryptamine 5-MeO-DALT (N,N-diallyl-5-methoxytryptamine): a brief review

Prog Neuropsychopharmacol Biol Psychiatry. 2012 Dec 3;39(2):259-62. doi: 10.1016/j.pnpbp.2012.05.022. Epub 2012 Jun 7.


5-MeO-DALT (N,N-diallyl-5-methoxytryptamine) is a psychoactive substance, sold primarily over the Internet as a 'research chemical' or 'plant food'. Although details for the synthesis of this tryptamine have been available since 2004, its use as a hallucinogenic drug has been reported only occasionally in on-line user fora. It is controlled in only a few countries world-wide. There is little scientifically-based literature on the pharmacological, physiological, psychopharmacological, toxicological and epidemiological characteristics of 5-MeO-DALT. Here we review what is known about these aspects. We also report what we believe to be the first death involving the use of this substance. The case involved a man in his mid-20s who died in mid-2010. The coroner concluded that the deceased "died from injuries sustained after being hit by a lorry whilst under the influence of 5-MeODALT". It is critical that any other cases, including non-fatal instances, are documented so that a scientific evidence-base can be established for this drug.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • 5-Methoxytryptamine / analogs & derivatives*
  • Allyl Compounds / administration & dosage
  • Allyl Compounds / pharmacology
  • Allyl Compounds / toxicity
  • Animals
  • Drug Administration Routes
  • Drug and Narcotic Control / trends
  • Humans
  • Illicit Drugs / pharmacology
  • Illicit Drugs / supply & distribution
  • Illicit Drugs / toxicity*
  • Tryptamines / administration & dosage
  • Tryptamines / pharmacology
  • Tryptamines / toxicity


  • Allyl Compounds
  • Illicit Drugs
  • Tryptamines
  • 5-Methoxytryptamine
  • N,N-diallyl-5-methoxytryptamine