Tracking evolution of BRCA1-associated breast cancer

Cancer Discov. 2012 Jun;2(6):486-8. doi: 10.1158/2159-8290.CD-12-0186.

Abstract

Single-cell profiling and computational identification of evolutionary paths to BRCA1-associated tumorigenesis predict that PTEN loss and TP53 mutation precede loss of wild-type BRCA1 in basal-like and luminal tumors, respectively.

Publication types

  • Comment

MeSH terms

  • BRCA1 Protein / genetics*
  • Breast Neoplasms / genetics*
  • Female
  • Humans
  • PTEN Phosphohydrolase / genetics*
  • Tumor Suppressor Protein p53 / genetics*

Substances

  • BRCA1 Protein
  • BRCA1 protein, human
  • TP53 protein, human
  • Tumor Suppressor Protein p53
  • PTEN Phosphohydrolase
  • PTEN protein, human