Molecular characterization of a new D- - haplotype in a Comorian man

Vox Sang. 2012 Nov;103(4):352-5. doi: 10.1111/j.1423-0410.2012.01620.x. Epub 2012 Jun 11.


The D- - phenotype is a genetic variant of the Rh blood group system. It expresses D antigen but lacks C, c, E and e antigens. In D- - phenotype, the RHCE coding region is extensively modified by RHD sequence replacement, nucleotide deletion or splice-site changes. This article reports the identification of a new D- - haplotype in a Comorian man. It exhibits a hybrid gene in which RHCE gene exons 3-8 have been replaced by RHD sequences on the RHCE * C allele background. This allele is associated with no expression of c/C and e/E antigens and overexpression of RhD antigen.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Group Antigens / genetics
  • Blood Group Antigens / immunology
  • Comoros
  • Epitopes / genetics
  • Epitopes / immunology
  • Haplotypes
  • Humans
  • Male
  • Phenotype
  • Rh-Hr Blood-Group System / genetics*
  • Rh-Hr Blood-Group System / immunology


  • Blood Group Antigens
  • Epitopes
  • Rh-Hr Blood-Group System
  • Rho(D) antigen