Progression to dementia in a population with amnestic mild cognitive impairment: clinical variables associated with conversion

Funct Neurol. Jan-Mar 2012;27(1):49-54.

Abstract

The aim of this study was to investigate clinical predictors of, and rates of conversion to, dementia syndrome in a case series of patients with amnestic mild cognitive impairment (aMCI). Two hundred and eight aMCI subjects were followed over a six-year period. A lower Mini Mental State Examination score was a significant predictor of dementia, and mild cognitive impairment patients with behavioral and psychiatric symptoms showed a faster conversion rate.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Amnesia / diagnosis
  • Amnesia / mortality*
  • Amnesia / physiopathology*
  • Cognitive Dysfunction / diagnosis
  • Cognitive Dysfunction / mortality*
  • Cognitive Dysfunction / physiopathology*
  • Dementia / diagnosis
  • Dementia / mortality*
  • Dementia / physiopathology*
  • Disease Progression
  • Female
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Mental Disorders / diagnosis
  • Mental Disorders / mortality
  • Mental Disorders / physiopathology
  • Predictive Value of Tests
  • Retrospective Studies