Load-bearing capacity and biological allowable limit of biodegradable metal based on degradation rate in vivo

J Biomed Mater Res B Appl Biomater. 2012 Aug;100(6):1535-44. doi: 10.1002/jbm.b.32722. Epub 2012 Jun 12.


In this study, a newly developed Mg-Ca-Zn alloy for low degradation rate and surface erosion properties was evaluated. The compressive, tensile, and fatigue strength were measured before implantation. The degradation behavior was evaluated by analyzing the microstructure and local hardness of the explanted specimen. Mean and maximum degradation rates were measured using micro CT equipment from 4-, 8-, and 16- week explants, and the alloy was shown to display surface erosion properties. Based on these characteristics, the average and minimum load bearing capacities in tension, compression, and bending modes were calculated. According to the degradation rate and references of recommended dietary intakes (RDI), the Mg-Ca-Zn alloy appears to be safe for human use.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorbable Implants*
  • Alloys / chemistry*
  • Calcium / chemistry*
  • Humans
  • Magnesium / chemistry*
  • Materials Testing*
  • Stress, Mechanical
  • X-Ray Microtomography
  • Zinc / chemistry*


  • Alloys
  • Magnesium
  • Zinc
  • Calcium