Abstract
Epstein Barr virus (EBV)-related diseases encompass both acute infections that result in acute infectious mononucleosis and chronic infections that result in lymphoproliferative malignant diseases. While classical inflammatory parameters such as C-reactive protein (CRP) have proven their usefulness during bacterial and fungal infections, they are often low and nondiscriminatory in viral infections. Here, we show that IL-18 is markedly elevated during acute EBV infections and EBV-associated diseases, while ferritin concentrations are also elevated during acute EBV infection and correlate with IL-18. Therefore, IL-18 and ferritin may represent infection markers for viral infections such as EBV, similar to CRP for bacterial infections.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adolescent
-
Adult
-
Antibodies, Viral / blood
-
Antigens, Viral / immunology
-
Biomarkers / blood
-
Capsid / immunology
-
DNA, Viral / isolation & purification
-
Enzyme-Linked Immunosorbent Assay
-
Epstein-Barr Virus Infections / blood*
-
Epstein-Barr Virus Infections / immunology
-
Epstein-Barr Virus Infections / pathology
-
Female
-
Ferritins / blood
-
Herpesvirus 4, Human / genetics
-
Herpesvirus 4, Human / immunology
-
Humans
-
Immunoglobulin G / blood
-
Immunoglobulin M / blood
-
Interleukin-18 / blood*
-
Male
-
Real-Time Polymerase Chain Reaction
-
Severity of Illness Index
-
Young Adult
Substances
-
Antibodies, Viral
-
Antigens, Viral
-
Biomarkers
-
DNA, Viral
-
Immunoglobulin G
-
Immunoglobulin M
-
Interleukin-18
-
Ferritins