Pulmonary endothelial cell injury and altered lung metabolic function. Early detection of the adult respiratory distress syndrome and possible functional significance

Clin Chest Med. 1990 Dec;11(4):723-36.


Markers of endothelial cell damage or dysfunction may be sensitive probes for the detection of the earliest phases of acute lung injury and may be a guide to the severity of injury or response to therapy as well. Depressed lung metabolic function may contribute to the intrapulmonary or systemic pathophysiology of ARDS.

Publication types

  • Review

MeSH terms

  • Animals
  • Endothelium / pathology
  • Hemodynamics
  • Humans
  • Lung / metabolism*
  • Lung / pathology
  • Respiratory Distress Syndrome / metabolism
  • Respiratory Distress Syndrome / physiopathology*
  • von Willebrand Factor / analysis


  • von Willebrand Factor