Cell and molecular biology underpinning the effects of PEDF on cancers in general and osteosarcoma in particular

J Biomed Biotechnol. 2012;2012:740295. doi: 10.1155/2012/740295. Epub 2012 May 28.

Abstract

Cancer is becoming an increasingly common disease in which abnormal cells aggressively grow, invade, and metastasize. In this paper, we review the biological functions of PEDF (pigmented epithelium-derived factor) against cancer, with a focus on a particular type of bone cancer called osteosarcoma. PEDF is a 50 kDa glycoprotein and is a potent inhibitor of angiogenesis, via its ability to decrease proliferation and migration of endothelial cells. This paper critically examines the anticancer activities of PEDF via its role in antiangiogenesis, apoptosis-mediated tumor suppression, and increased tumor cell differentiation. Recently, an orthotopic model of osteosarcoma was used to show that treatment with PEDF had the greatest impact on metastases, warranting an evaluation of PEDF efficacy in other types of cancers.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiogenesis Inhibitors / pharmacology
  • Angiogenesis Inhibitors / therapeutic use
  • Animals
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Bone Neoplasms / blood supply
  • Bone Neoplasms / drug therapy*
  • Bone Neoplasms / pathology
  • Eye Proteins / pharmacology*
  • Eye Proteins / therapeutic use
  • Humans
  • Neoplasms / blood
  • Neoplasms / drug therapy*
  • Neoplasms / pathology
  • Neovascularization, Pathologic / drug therapy
  • Nerve Growth Factors / pharmacology*
  • Nerve Growth Factors / therapeutic use
  • Osteosarcoma / blood supply
  • Osteosarcoma / drug therapy*
  • Osteosarcoma / pathology
  • Serpins / pharmacology*
  • Serpins / therapeutic use

Substances

  • Angiogenesis Inhibitors
  • Antineoplastic Agents
  • Eye Proteins
  • Nerve Growth Factors
  • Serpins
  • pigment epithelium-derived factor