Role of N-terminal pro-brain natriuretic peptide in detecting clinically significant cardiac involvement in systemic sclerosis patients

Clin Exp Rheumatol. 2012 Mar-Apr;30(2 Suppl 71):S81-5. Epub 2012 May 29.


Objectives: Cardiac involvement is recognised as a poor prognostic factor among systemic sclerosis (SSc) patients, contributing significantly to mortality. We assessed the role of N-TproBNP in SSc-related cardiac involvement in a retrospective cohort of patients.

Methods: Serum N-TproBNP levels were measured in 21 SSc patients with clinically significant cardiac involvement and in a control group of 42 SSc patients without any evidence of heart involvement. All patients had normal pulmonary artery systolic pressure and none had serum creatinine above 140 micromol/L.

Results: Compared with those without cardiac involvement, N-TproBNP was significantly increased in SSc patients with heart involvement (median 11 and 219 pmol/L respectively, p<0.0001; CI 136-445). Receiver operating characteristic curves of N-TproBNP to predict the presence of cardiac involvement in SSc gave a sensitivity of 90.5% at a cut-off level of 50 pmol/L, with a specificity of 97.6%. By logistic regression analysis, N-TproBNP levels of 50 pmol/L were shown to be a strong predictor of heart involvement (OR 78, p<0.001, 95%CI 14-424). Moreover, a significant progressive reduction in N-TproBNP after initial presentation of cardiac involvement was observed in a subset of patients during 6 months of follow-up (p=0.023). Levels of N-TproBNP above the median value of 219 pmol/L did not predict survival (p=0.895, by log-rank). N-TproBNP levels strongly correlated negatively with LVEF (r=-0.7384, p=0.0002).

Conclusions: These data suggest N-TproBNP peptide may be a surrogate marker for cardiac involvement in SSc, selectively identifying patients with severe impairment of cardiac function.

MeSH terms

  • Adult
  • Aged
  • Biomarkers / blood
  • Female
  • Heart Diseases / blood
  • Heart Diseases / diagnosis
  • Heart Diseases / etiology*
  • Heart Diseases / mortality
  • Heart Diseases / physiopathology
  • Humans
  • Kaplan-Meier Estimate
  • Logistic Models
  • London
  • Male
  • Middle Aged
  • Natriuretic Peptide, Brain / blood*
  • Odds Ratio
  • Peptide Fragments / blood*
  • Predictive Value of Tests
  • ROC Curve
  • Retrospective Studies
  • Scleroderma, Systemic / blood
  • Scleroderma, Systemic / complications*
  • Scleroderma, Systemic / mortality
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Stroke Volume
  • Up-Regulation
  • Ventricular Function, Left


  • Biomarkers
  • Peptide Fragments
  • pro-brain natriuretic peptide (1-76)
  • Natriuretic Peptide, Brain