KiSS1 and its G-protein-coupled receptor GPR54 in cancer development and metastasis

Cancer Metastasis Rev. 2012 Dec;31(3-4):585-91. doi: 10.1007/s10555-012-9367-7.

Abstract

KiSS1 and its cognate G-protein-coupled receptor, GPR54, have diverse functions. While KiSS1 and GPR54 have been intensively studied in physiology, their role in cancer is still unclear. In cancer, KiSS1 and GPR54 have been known to suppress metastasis by inhibiting cancer cell motility. However, recent studies suggest that KiSS1 and GPR54 have varied roles even in cancer development and metastasis. Here, we examine recent advances in understanding the roles of KiSS1 and GPR54 in cancer development and metastasis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Kisspeptins / physiology*
  • Neoplasm Metastasis*
  • Neoplasms / etiology*
  • Receptors, G-Protein-Coupled / physiology*
  • Receptors, Kisspeptin-1
  • Signal Transduction

Substances

  • KISS1 protein, human
  • KISS1R protein, human
  • Kisspeptins
  • Receptors, G-Protein-Coupled
  • Receptors, Kisspeptin-1