Two new chlorophenyl glycosides from the bulbs of Lilium brownii var. viridulum

J Asian Nat Prod Res. 2012;14(8):769-75. doi: 10.1080/10286020.2012.691096. Epub 2012 Jun 14.

Abstract

Two rare new chlorophenyl glycosides, 2,4,6-trichlorol-3-methyl-5-methoxy-phenol 1-O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranoside (1) and 4-chlorol-5-hydroxyl-3-methyl-phenol 1-O-α-L-rhamnopyranosyl-(1 → 6)-β-D-glucopyranoside (2), along with three known compounds (3-5) were isolated from the bulbs of Lilium brownii var. viridulum. The structures of the new compounds were elucidated on the basis of spectroscopic and chemical methods. All the compounds exhibited weak inhibition of NO production in LPS-stimulated RAW 264.7 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Glycosides / chemistry
  • Glycosides / isolation & purification*
  • Hydrocarbons, Chlorinated / chemistry
  • Hydrocarbons, Chlorinated / isolation & purification*
  • Lilium / chemistry*
  • Lipopolysaccharides / pharmacology
  • Macrophages / drug effects
  • Mice
  • Molecular Structure
  • Nitric Oxide / biosynthesis
  • Plant Roots / chemistry

Substances

  • 2,4,6-trichlorol-3-methyl-5-methoxy-phenol 1-O-beta-D-glucopyranosyl-(1-6)-beta-D-glucopyranoside
  • 4-chlorol-5-hydroxyl-3-methyl-phenol 1-O-alpha-L-rhamnopyranosyl-(1-6)-beta-D-glucopyranoside
  • Glycosides
  • Hydrocarbons, Chlorinated
  • Lipopolysaccharides
  • Nitric Oxide