Management of epilepsy associated with tuberous sclerosis complex (TSC): clinical recommendations

Eur J Paediatr Neurol. 2012 Nov;16(6):582-6. doi: 10.1016/j.ejpn.2012.05.004. Epub 2012 Jun 12.


Tuberous sclerosis complex (TSC) is a leading genetic cause of epilepsy. TSC-associated epilepsy generally begins during the first year of life, and is associated with neurodevelopmental and cognitive problems. Management is challenging and seizures tend to persist in a large proportion of patients despite pharmacological and surgical treatment. This report summarizes the clinical recommendations for the management of TSC-associated epilepsy made by a panel of European experts in March 2012. Current treatment options and outstanding questions are outlined.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anticonvulsants / therapeutic use
  • Child
  • Child, Preschool
  • Consensus
  • Diet, Ketogenic
  • Epilepsy / drug therapy
  • Epilepsy / etiology*
  • Epilepsy / surgery
  • Epilepsy / therapy*
  • Guidelines as Topic
  • Humans
  • Infant
  • Infant, Newborn
  • Neurosurgical Procedures
  • TOR Serine-Threonine Kinases / antagonists & inhibitors
  • Tuberous Sclerosis / complications*
  • Vagus Nerve Stimulation


  • Anticonvulsants
  • MTOR protein, human
  • TOR Serine-Threonine Kinases