Na(+),K (+)-ATPase as a docking station: protein-protein complexes of the Na(+),K (+)-ATPase

Cell Mol Life Sci. 2013 Jan;70(2):205-22. doi: 10.1007/s00018-012-1039-9. Epub 2012 Jun 14.


The Na(+),K(+)-ATPase, or sodium pump, is well known for its role in ion transport across the plasma membrane of animal cells. It carries out the transport of Na(+) ions out of the cell and of K(+) ions into the cell and thus maintains electrolyte and fluid balance. In addition to the fundamental ion-pumping function of the Na(+),K(+)-ATPase, recent work has suggested additional roles for Na(+),K(+)-ATPase in signal transduction and biomembrane structure. Several signaling pathways have been found to involve Na(+),K(+)-ATPase, which serves as a docking station for a fast-growing number of protein interaction partners. In this review, we focus on Na(+),K(+)-ATPase as a signal transducer, but also briefly discuss other Na(+),K(+)-ATPase protein-protein interactions, providing a comprehensive overview of the diverse signaling functions ascribed to this well-known enzyme.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Transport, Active
  • Cell Membrane / metabolism*
  • Humans
  • Ion Transport
  • Multiprotein Complexes / metabolism
  • Potassium / metabolism*
  • Protein Binding
  • Protein Structure, Tertiary
  • Signal Transduction
  • Sodium / metabolism*
  • Sodium-Potassium-Exchanging ATPase / chemistry
  • Sodium-Potassium-Exchanging ATPase / metabolism*


  • Multiprotein Complexes
  • Sodium
  • Sodium-Potassium-Exchanging ATPase
  • Potassium