Neuronal cadherin (NCAD) increases sensory neurite formation and outgrowth on astrocytes

Neurosci Lett. 2012 Aug 1;522(2):108-12. doi: 10.1016/j.neulet.2012.06.013. Epub 2012 Jun 12.


We examined the neurite outgrowth of sensory neurons on astrocytes following the genetic deletion of N-cadherin (NCAD). Deletion abolished immunostaining for NCAD and the other classical cadherins, indicating that NCAD is likely the only classical cadherin expressed by astrocytes. Only 38% of neurons grown on NCAD-deficient astrocytes for 24 h produced neurites, as compared to 74% of neurons grown on NCAD-expressing astrocytes. Of the neurons that produced neurites, those grown on NCAD-deficient astrocytes had a mean total length of 378 μm, as compared to 1093 μm for neurons grown on NCAD-expressing astrocytes. Thus, the loss of NCAD greatly impairs the formation and extension neurites on astrocytes.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Animals, Newborn
  • Astrocytes / physiology*
  • Astrocytes / ultrastructure
  • Cadherins / genetics
  • Cadherins / physiology*
  • Cells, Cultured
  • Dependovirus / genetics
  • Ganglia, Spinal / cytology
  • Mice
  • Neurites / physiology*
  • Sensory Receptor Cells / physiology*
  • Sensory Receptor Cells / ultrastructure


  • Cadherins