Review
doi: 10.1097/ACO.0b013e32835561de.
Conscious processing: implications for general anesthesia
Affiliations
- PMID: 22699320
- DOI: 10.1097/ACO.0b013e32835561de
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Review
Conscious processing: implications for general anesthesia
Curr Opin Anaesthesiol.
2012 Aug.
Abstract
Purpose of review: Can a general anesthetic binding to its membrane receptors alter global brain activity to cause loss of consciousness?
Recent findings: The identification of the neurobiological mechanisms of conscious processing in awake patients that are altered by general anesthetics and the atomic structure of the general anesthetic's binding site.
Summary: An important feature of general anesthesia is a preferential inhibition of global feedback connectivity when general anesthetics bind to allosteric sites of gamma-aminobutyric acid receptors present in the cerebral cortex.
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