Mammalian Sulf1 RNA alternative splicing and its significance to tumour growth regulation

Tumour Biol. 2012 Oct;33(5):1669-80. doi: 10.1007/s13277-012-0423-2. Epub 2012 Jun 15.


SULF1/SULF2 enzymes regulate the activities of several growth factors by selective hydrolysis of 6-O-sulphates of heparan sulphate proteoglycan co-receptors, the sulfation of which is essential for signal transduction of some ligand/receptor interactions but not others. This study demonstrates the existence of SULF1 variants with a wide spectrum of splicing patterns in mammalian tumours. The levels and relative proportions of SULF1/SULF2 splice variants markedly vary in different tumours with a potential to regulate cell growth differentially. Although mammalian Sulf1 compared with Sulf2 gene generates a much larger number of splice variants, both enzymes follow generally similar distribution and signalling association trends in hepatocellular carcinomas.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alternative Splicing*
  • Animals
  • Carcinoma, Hepatocellular / genetics
  • Carcinoma, Hepatocellular / metabolism
  • Cell Proliferation
  • Gene Expression Regulation
  • Humans
  • Isoenzymes
  • Liver / metabolism
  • Liver Neoplasms / genetics
  • Liver Neoplasms / metabolism
  • Neoplasms / genetics*
  • Neoplasms / metabolism
  • Signal Transduction
  • Sulfotransferases / genetics*
  • Sulfotransferases / metabolism
  • Wnt Proteins / metabolism


  • Isoenzymes
  • Wnt Proteins
  • Sulfotransferases