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. 2012 Jun 8:3:145.
doi: 10.3389/fimmu.2012.00145. eCollection 2012.

The immunobiology of Leishmania braziliensis infection

Camila I de Oliveira  1 , Claudia I Brodskyn
Affiliations

The immunobiology of Leishmania braziliensis infection

Camila I de Oliveira et al. Front Immunol. .

Abstract

Leishmaniases are a group of diseases caused by protozoa of the genus Leishmania that affect millions of people worldwide. These diseases are caused by distinct Leishmania species, of which L. braziliensis, a New World representative of the Leishmania genus, has been the least studied. Although leishmaniasis caused by L. braziliensis induces a range of clinical manifestations ranging from mild localized lesions to severe mucosal involvement, few studies have focused on elucidating the immune mechanisms behind this pathology. In this review, we focus on the immunobiology of L. braziliensis infection, emphasizing the innate and adaptive immune responses and taking into consideration both studies performed in endemic areas and experimental models of infection. Additionally, we address recent findings regarding the role of sand fly saliva in disease immunopathogenesis and vaccine development.

Keywords: Leishmania braziliensis; animal models; human adaptive immunology; innate immunity.

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References

    1. Afonso L., Borges V. M., Cruz H., Ribeiro-Gomes F. L., DosReis G. A., Dutra A. N., Clarencio J., de Oliveira C. I., Barral A., Barral-Netto M., Brodskyn C. I. (2008). Interactions with apoptotic but not with necrotic neutrophils increase parasite burden in human macrophages infected with Leishmania amazonensis. J. Leukoc. Biol. 84 389–396 - PubMed
    1. Anderson C. F., Oukka M., Kuchroo V. J., Sacks D. (2007). CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J. Exp. Med. 204 285–297 - PMC - PubMed
    1. Antonelli L. R., Dutra W. O., Almeida R. P., Bacellar O., Gollob K. J. (2004). Antigen specific correlations of cellular immune responses in human leishmaniasis suggests mechanisms for immunoregulation. Clin. Exp. Immunol. 136 341–348 - PMC - PubMed
    1. Antonelli L. R., Dutra W. O., Almeida R. P., Bacellar O., Carvalho E. M., Gollob K. J. (2005). Activated inflammatory T cells correlate with lesion size in human cutaneous leishmaniasis. Immunol. Lett. 101 226–230 - PubMed
    1. Bafica A., Oliveira F., Freitas L. A., Nascimento E. G., Barral A. (2003). American cutaneous leishmaniasis unresponsive to antimonial drugs: successful treatment using combination of N-methilglucamine antimoniate plus pentoxifylline. Int. J. Dermatol. 42 203–207 - PubMed

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