Nitric oxide inhibitory activity of monogalactosylmonoacylglycerols from a freshwater microalgae Chlorella sorokiniana

Nat Prod Res. 2013;27(11):1028-31. doi: 10.1080/14786419.2012.696255. Epub 2012 Jun 18.

Abstract

Chemical investigation of the freshwater microalgae Chlorella sorokiniana led to the isolation of a new monogalactosylmonoacylglycerol, namely, (2S)-1-O-(7Z,10Z-hexadecadienoyl)-3-O-β-D-galactopyranosylglycerol (1) together with a known glycolipid (2S)-1-O-(7Z,10Z,13Z-hexadecatrienoyl)-3-O-β-D-galactopyranosylglycerol (2). Both monogalactosylmonoacylglycerols showed dose-dependent nitric oxide (NO) inhibitory activity against lipopolysaccharide-induced NO production in RAW264.7 macrophage cells suggesting their possible use as anti-inflammatory agents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chlorella / chemistry*
  • Fresh Water
  • Glycerol / chemistry
  • Glycerol / pharmacology*
  • Nitric Oxide / antagonists & inhibitors*

Substances

  • Nitric Oxide
  • Glycerol